16.07.2012
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Announcements / Press Releases
Saving lives and sustaining development gains: The social and economic benefits of malaria control [G20 Malaria special feature] — (English)
As the world continues to reel from the aftershocks of various financial crises, finance ministers and central bank governors from the G20 countries meet in Mexico in June to find ways to promote sustainable growth and economic stability. Low-income countries will be particularly hard hit as the European debt crisis worsens – they are likely to suffer froma decline in development aid; from falling income as demand from Europe diminishes; and from decreasing revenue from migrants. They may also see the unravelling of their recent development gains...
Global Fund Releases an Analysis of Audits and Investigations – 2012 [The Global Fund News release] — (English)
The Global Fund to Fight AIDS, Tuberculosis and Malaria reported today that an analysis of audits and investigations by the Office of the Inspector General showed that 3.0 percent of funding audited or investigated between 2005 and 2012 had been misspent, fraudulently misappropriated or inadequately accounted for...
GFO Issue 189 [www.aidspan.org] — (English)
July 2012 issue...
US Senate Agrees on New Malaria Resolution [RBM] — (English)
The Senate of the United States of America agreed to a new resolution supporting the goals and ideals of World Malaria Day, including the target of ending malaria deaths by 2015. It reaffirmed US leadership and support for efforts to combat malaria as a critical component of the President's Global Health Initiative...
CECAFA Dedicates Kagame Cup 2012 to Fight Against Malaria [UAM] — (English)
CECAFA partners with United Against Malaria to bring life-saving messages to football fans of Central and East Africa and to urge leaders to invest in malaria control for a healthier continent...
UAM's Role as Official Social Cause for Africa Cup of Nations 2013 Highlighted During Play-Off Draw [UAM] — (English)
The Confederation of African Football (CAF) has named the United Against Malaria (UAM) campaign as an official social program of the 2013 Orange Africa Cup of Nations. Highlighted at the Orange Africa Cup of Nations 2013 playoff draw in Johannesburg this week, in conjunction with the Local Organizing Committee (LOC) of the South African Football Association (SAFA), the role of the tournament in disseminating messages about the prevention and treatment of malaria to millions of African football fans was reinforced...
How malaria evades the body's immune response [YaleNews] — (English)
The mosquito-borne parasites that cause human malaria and make it particularly lethal have a unique ability to evade destruction by the body's immune system, diminishing its ability to develop immunity and fight the infection, a Yale study has found. The study appears in the Online Early Edition of the Proceedings of the National Academy of Sciences...
Innovations in malaria slide reading [MRC The Gambia Unit] — (English)
Faster, more accurate data management: every researcher's wish. Now a new system being piloted in the malaria research lab at MRC Unit, The Gambia promises just that. Having looked for a computerised slide reading system and finding none, Database Developer Safayet Hossin has designed one in just four months and it promises to improve not only efficiency but also the quality of malaria slide reading...
La Toile [WHO/AFRO] — (English)
WHO/AFRO Malaria Newsletter, Vol. 4 No. 1, June 2012...
DNRi's Annual Report 2011 [DNDi] — (English)
Through its annual reports, DNDi publishes the main achievements of its R&D projects and activities, and provides comprehensive information about the organization's performance and latest accomplishments in the field of neglected diseases...
Developing and delivering new treatments to combat poverty-related neglected diseases [DNDi] — (English)
DNDi new brochure...
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Articles requiring subscription or registration
Are insecticide treated bednets failing? [The Lancet Infectious Diseases, Volume 12, Issue 7, Page 512, July 2012 doi:10.1016/S1473-3099(12)70105-6] — (English)
Jean-Francois Trape and colleagues1 report an increase in the incidence of clinical attacks of malaria after the introduction of treated bednets in Dielmo, Senegal, and equate this increase with vectors' resistance to insecticides. However, we believe that their analyses and conclusions have several weaknesses...
Enhancement of dendritic cell activation via CD40 ligand-expressing γδ T cells is responsible for protective immunity to Plasmodium parasites [PNAS 10.1073/pnas.1204480109] — (English)
Here, we found that γδ T cells play a key role in dendritic cell activation after Plasmodium infection...
A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria [PNAS 0.1073/pnas.1206573109] — (English)
These findings indicate that Plasmodia actively interfere with the development of immunological memory and may account for the evolutionary conservation of parasite macrophage migration inhibitory factor orthologs...
Source of Clinical Malaria in Mixed-Species Infections [Journal of Travel Medicine Volume 19, Issue 4, page 275, July 2012] — (English)
Correspondence...
Intermittent preventive treatment of malaria in pregnant women and infants: making best use of the available evidence [Expert Opinion on Pharmacotherapy] — (English)
This review examines all the available information on IPT, in an aim to provide the scientific community with a framework to understand the benefits and limitations of this malaria control strategy...
Postmortem Characterization of Patients with Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent does this Parasite Kill? [Clin Infect Dis. (2012) doi: 10.1093/cid/cis615] — (English)
In 13 out of the 17 deceased patients, P. vivax infection was the plausible cause of death. However, more studies are needed to understand pathogenesis related to severe disease...
Mission against malaria [Nature Medicine 18, 1008 (2012) doi:10.1038/nm.2774] — (English)
Lifeblood focuses on the efforts of entrepreneur and multimillionaire Ray Chambers, the Special Envoy for Malaria of the Secretary General of the United Nations, to help eradicate malaria in Africa by aiding in the distribution of insecticide-impregnated bed nets through his nongovernmental organization Malaria No More (MNM). Alex Perry, Time magazine's Africa bureau chief, reports on his travels with Chambers and writes about malaria, which has haunted Africa for at least 10,000 years...
Anopheles (Cellia) maculatus group: its spatial distribution and molecular characterization of member species in north-east India [Acta Tropica] — (English)
Our study encompassing 410 individuals, collected from 67 geo-referenced spots across the eight north-east Indian states, identified the presence of 6 member species of the Maculatus group using the molecular tools...
Vector capacity of Anopheles sinensis in malaria outbreak areas of central China [Parasites & Vectors 2012, 5:136 doi:10.1186/1756-3305-5-136] — (English)
This study suggests that vivax malaria outbreaks in Huanhuai valley is highly related to the enhancement in vector capacity of An. sinensis for P. vivax, which is attributed to the local residents' habits and the remarkable drop in the number of large livestock leading to disappearance of traditional biological barriers...
Structural basis for chirality and directional motility of Plasmodium sporozoites [Cellular Microbiology DOI: 10.1111/j.1462-5822.2012.01836.x] — (English)
Here we determined the structural basis that underlies this type of movement. Immature, non-motile sporozoites were found to lack the subpellicular network required for obtaining the crescent parasite shape...
In vitro human cell-free expression system for synthesis of malaria proteins [PARASITOLOGY RESEARCH 2012, DOI: 10.1007/s00436-012-3014-7] — (English)
In this study, we performed cell-free expression of Plasmodium proteins using the in vitro human cell-free protein expression systems for DNA and mRNA...
Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in vivo Studies, and Preliminary Toxicity Profiling [J. Med. Chem., Just Accepted Manuscript DOI: 10.1021/jm300802s] — (English)
Here we describe the optimization of this class of hybrid drug through in depth structure-activity relationship studies...
Early skin immunological disturbance after Plasmodium-infected mosquito bites [Cellular Immunology] — (English)
In this paper we show that sporozoites introduced into the skin by mosquito bites increase the mobility of skin Tregs and dendritic cells (DCs)...
Superinfection and the evolution of resistance to antimalarial drugs [Proc Biol Sci. 10.1098/rspb.2012.1064] — (English)
We developed a general theory for modelling the evolution of resistance with host superinfection and examine: (i) the effect of transmission intensity on the rate of resistance evolution; (ii) the importance of different biological costs of resistance; and (iii) the best measure of the frequency of resistance...
Induction of antisporozoite antibodies by biting of transgenic Anopheles stephensi delivering malarial antigen via blood feeding [Insect Molecular Biology Volume 21, Issue 2, pages 223–233, April 2012] — (English)
We produced a transgenic mosquito expressing a rodent malaria vaccine candidate antigen in the salivary gland...
Establishment of exotic parasites: the origins and characteristics of an avian malaria community in an isolated island avifauna [Ecology Letters DOI: 10.1111/j.1461-0248.2012.01833.x] — (English)
Our results show that avian malaria parasites (AM; parasites of the genus Plasmodium) that successfully invaded are more globally generalist (both geographically widespread and with a broad taxonomic range of hosts) than AM parasites not co-introduced to New Zealand...
Perceived causes of severe mental illness and preferred interventions by the Borana semi-nomadic population in southern Ethiopia: a qualitative study [BMC Psychiatry 2012, 12:79 doi:10.1186/1471-244X-12-79] — (English)
These findings will be of value for health care planners who wish to expand modern mental health care to this population, indicating the need to increase awareness about the causes of severe mental disturbance and their interventions and collaborate with influential people and indigenous healers to increase acceptability of modern mental health care. It also provides information for further research in the area of mental health in this semi-nomadic population...
Using community health workers in community-based growth promotion: what stakeholders think [Health Educ. Res. (2012) doi: 10.1093/her/cys083] — (English)
The purpose of this study was to identify perceptions of key stakeholders about the project and the role of the CCGPs. The study employed qualitative methods: focus group discussions with CCGPs and care givers, exit interviews with care givers, and key informant interviews with health workers and CCGPs...
Molecular Characterization and Mutational Analysis of Recombinant Diadenosine 5′,5″-P1,P4-Tetraphosphate Hydrolase from Plasmodium falciparum [Biological and Pharmaceutical Bulletin Vol. 35 (2012) No. 7 p. 1191-1196] — (English)
Asymmetrical diadenosine 5′,5″-P1,P4-tetraphosphate hydrolase (EC 3.6.1.17) from human malaria parasite Plasmodium falciparum was expressed in Escherichia coli, purified to homogeneity, and characterized for the first time as a biological target for chemotherapeutic agents against malaria...
Clinical aspects and outcome of suspected severe pediatric malaria [Médecine et Maladies Infectieuses] — (English)
Poor technical support and inadequate organization of the patient circuit can result in underestimating the metabolic complications of severe malaria and of other severe infections of early childhood. This is detrimental to the patients, even when effective drugs are available...